Daily Dose Guide Your Progressive One-Stop Guide to Daily Dosage

Bromelain Dosage

Daily Dose of Bromelain: 80-320mg, 2-3 times a day

Supplementing with Bromelain

Bromelain is an enzyme that can be found in the core of a pineapple. Photo Credit: https://www.flickr.com/photos/7304492@N06/

Bromelain, or bromelin, is an enzyme that contains sulfur and is naturally occurring near the core of pineapples. People take bromelain for its anti-inflammatory and pain relieving properties. When taken with other substances such as rutin and trypsin, it relieves pain and improves joint function among people with osteoporosis. It was discovered in a study that it may also relieve knee pain not caused by arthritis, sinus infection, recovery from surgery, and colitis. When applied topically as a cream, it may also relieve rashes and burns. It even has anti-tumor activity when taken during chemotherapy. One notable study of bromelain reports that it promotes the reabsorption of fluid into the blood circulation. Alongside this action is its ability to break down fibrin, a blood-clotting protein. These are all very important for therapeutic use of bromelain in conditions of edema. It is recognized because it can prevent edema and significantly reduce active edema by 50% when taken orally. In several countries, bromelin is used to enhance antiobiotics, making them more potent. In a study, bromelain was used with penicillins and tetracycline antibiotics. The results showed higher levels found in the tissues and blood, but a reduction in the side effects normally caused by those substances.

There is no standard dose of bromelain because the doses vary depending on what it’s used for. Swelling, for example, would need a dosage of about 80-320mg taken 2-3 times a day. For knee pain, 1-2 tablets of 200mg are used to relieve the pain. Some side effects that you might expect from taking this supplement include stomach upset, diarrhea, vomiting, rapid heartbeat, and heavy menstrual periods. It may even trigger allergies in people who are allergic to pineapples, certain pollens, carrots, celery, rye and wheat flour, latex, bee venom, and other substances. Bromelain can increase the risk of bleeding because it can inhibit blood clotting. People on blood thinning medication should be careful when taking this.



  • Ordesi P, Pisoni L, Nannei P, Macchi M, Borloni R, Siervo S. Therapeutic efficacy of bromelain in impacted third molar surgery: a randomized controlled clinical study. Quintessence Int. 2014 Sep;45(8):679-84. PMID: 25019111.
  • Fouz N1, Amid A, Hashim YZ. Gene expression analysis in mcf-7 breast cancer cells treated with recombinant bromelain. Appl Biochem Biotechnol. 2014 Aug;173(7):1618-39. PMID: 24928548.
  • Müller S1, März R, Schmolz M, Drewelow B, Eschmann K, Meiser P. Placebo-controlled randomized clinical trial on the immunomodulating activities of low- and high-dose bromelain after oral administration – new evidence on the antiinflammatory mode of action of bromelain. Phytother Res. 2013 Feb;27(2):199-204. PMID: 22517542.

Add a Daily Dose Anecdote

You must be logged in to post a comment.

You might also like the guide to:close