Daily Dose of Coluracetam: 200mg
Coluracetam is one of the newest members of the racetam family of smart drugs. It was synthesized in Japan and derived from Piracetam as a treatment for Major Depressive Disorder (MDD) and also general anxiety problems. It showed promise in treating patients with both disorders but did not show significant results with patients who only have one of these disorders. The good news is it can do more than just treat these disorders. One of the notable benefits of coluracetam is long-term improvements in memory-impaired individuals. Not many human tests have been done to prove this benefit at this point but animal experiments serve as the best evidence.
Animal testing of coluracetam was done on rats to observe the improvement of their memory by using a commonly accepted maze test. Memory improvements also continued even after coluracetam left their system, indicating some type of long-term effect. Other reports have indicated that this supplement, like other nootropics, helped to improve memory, cognition, decision making, and even vision. It gets its name from its notable effects on vision, making shapes and colors more vivid. It works by increasing Choline uptake into neurons regardless if they are already impaired or damaged.
Coluracetam is considered relatively safe because of the methods of action and similar structure to other Racetam supplements. However, research on this supplement is still limited so there isn’t much information on side effects or toxicity. Researchers reported that they did not observe any negative side effects when dosages were up to 80mg three times a day. There is no standard recommended dosage for this supplement yet but studies have used up to 200mg a day for the average person. For people taking this supplement to treat major depressive disorder, taking up to 100 mg three times daily has shown to be effective.
- Bessho T1, Takashina K, Eguchi J, Komatsu T, Saito K. MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats. J Neural Transm. 2008 Jul;115(7):1019-25. PMID: 18461272.
- Takashina K1, Bessho T, Mori R, Kawai K, Eguchi J, Saito K. MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake. J Neural Transm. 2008 Jul;115(7):1037-46. PMID: 18461273.