Octopamine Dosage

Daily Dose of Octopamine: 100-200mg

Octopamine can be found in bitter orange. Photo Credit: https://www.flickr.com/photos/15216811@N06/

Octopamine can be found in bitter orange.
Photo Credit: https://www.flickr.com/photos/15216811@N06/

Octopamine, although not as popular as many other nootropics, it is now getting more attention because of its many benefits. Besides enhancing focus, one of the things that makes it unique is that it is an energy and wakefulness booster. It is a biogenic amine that is closely related to the hormone norepinephrine and thus is sometimes referred to as Norsynephrine or β, 4-dihydroxyphenethylamine. The way it functions as a neurotransmitter is also believed to be similar to norepinephrine. Because of its similarities, it may have the same effects as norepinephrine such as an increase in heart rate, increased metabolism, better release of glucose for energy use, as well as an increase in the overall blood flow to skeletal muscles.

Octopamine is not extensively used as a nootropic but it does have notable effects like increasing energy, alertness, vigilance, and awareness. Many people decide to use it when they need to focus for long periods of time or increase their motivation when they need to work on a project at work or school. It is similar to and often compared to Ritalin or Adderall because of these reasons but many students and some in the nootropic community still prefer to take Ritalin or Modafinil. The most common use of this supplement is as a fat burner and weight loss aid. Because of this it is popular among bodybuilders. It causes the breakdown of fat cells in the body by stimulating beta3 adrenergic receptors. Unlike most fat burning agents, Octopamine is less likely to lose its effectiveness over longer periods of time. This is a significant benefit because most other fat burners tend to only work for a few weeks. Another way it helps people lose weight is that it boosts metabolism so more calories can be burned.

There have not been enough human research to determine a recommended dosage for Octopamine although most people have found success in taking 100-200mg per day. It is always a good choice to start out with a small dose and gradually increase it as you become familiar with its effects. This is considered to be a safe supplement and is well tolerated by healthy adults when taking the proper doses. The only reported side effect is an increase in blood pressure so if you already have high blood pressure you should ask your doctor first before taking it.



  • Scheiner R1, Steinbach A2, Claßen G3, Strudthoff N3, Scholz H4. Octopamine indirectly affects proboscis extension response habituation in Drosophila melanogaster by controlling sucrose responsiveness. J Insect Physiol. 2014 May 10. PMID: 24819202.
  • Stohs SJ. Physiological functions and pharmacological and toxicological effects of p-octopamine. Drug Chem Toxicol. 2014 Mar 24. PMID: 24654910.

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