Daily Dose Guide Your Progressive One-Stop Guide to Daily Dosage

Phenylalanine Dosage

Daily Dose of Phenylalanine: 50-100mg/kg

Supplementing with Phenylalanine

Egg whites are a great source of Phenylalanine.
Photo Credit: http://www.flickr.com/photos/sifu_renka/

It’s natural to feel sad every once in a while but if the feeling is reoccurring and it interferes with life or doesn’t go away, it may be depression. About 19 million Americans suffer from some form of depression. What is depression? Depression is actually more than just the feeling of sadness. It can be the feeling of emptiness, fatigue, and hopelessness. People who suffer from depression often feel the loss of interest in doing things they used to love doing. The main difference between sadness and depression is that depression can interfere with normal daily activities, even getting out of bed can be challenging. Phenylalanine is an essential amino acid that needs to be taken through your diet. There are 3 forms of the amino acid; L-Phenylalanine, D-Phenylalanine and DL-Phenylalanine, which is a combination of the first two. Phenylalanine is required to make the neurotransmitters seratonin, epinephrine, and norepinephrine in the brain. This leads to improving the effectiveness of antidepressants. However, it only works as a boost for antidepressents, not a replacement. Besides depression, it may also be used to treat Adult ADHD by improving the mood of adults.

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Phenylalanine can be found in many foods that are protein rich, including eggs, meats, fish, and dairy. Some side effects of may occur when taken in high doses. These side effects include nausea, heartburn, and headaches. A high dose of 5,000mg per day can cause serious nerve damage. People who have phenylketonuris cannot metabolize phenylalanine and thus should not take it to avoid serious illness. This supplement should not be taken without the supervision of your doctor. It changes the effectiveness of the antidepressants as well as other drugs. Talking to your doctor will avoid any unwanted interactions.

Sources:
http://www.livestrong.com/article/433423-l-phenylalanine-and-depression/

http://www.webmd.com/vitamins-supplements/ingredientmono-653-PHENYLALANINE.aspx?activeIngredientId=653&activeIngredientName=PHENYLALANINE
http://www.mayoclinic.org/phenylalanine/expert-answers/faq-20058361

References

  • Conway CR1, Chibnall JT2, Cumming P3, Mintun MA4, Gebara MA5, Perantie DC5, Price JL6, Cornell ME5, McConathy JE7, Gangwani S5, Sheline YI8. Antidepressant response to aripiprazole augmentation associated with enhanced FDOPA utilization in striatum: A preliminary PET study. Psychiatry Res. 2014 Mar 30;221(3):231-9. PMID: 24468015.
  • Stevenson M1, McNaughton N. A comparison of phenylketonuria with attention deficit hyperactivity disorder: do markedly different aetiologies deliver common phenotypes? Brain Res Bull. 2013 Oct;99:63-83. PMID: 24140048.

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