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Sulbutiamine Dosage

Daily Dose of Sulbutiamine: 200-500mg 2 times a day

Supplementing with Sulbutiamine

Sulbutiamine has been shown to help improve memory, learning capacity, decision-making and more.
Photo Credit: https://www.flickr.com/photos/23771587@N08/

Sulbutiamine is derived from thiamine, or Vitamin B1. It was created by Japanese researches because they were looking for a way to make thiamine more easily absorbed. Thiamine is known to improve cognitive function but it has a very low absorption rate and not much of the substance arrives at the brain to actually increase factors related to intelligence. Sulbutiamine fixes this problem by making this essential nutrient lipid soluble so that it is more easily absorbed into the blood. This alteration of thiamine makes it capable of crossing the blood-brain barrier in greater volume, where it can communicate with your central nervous system. This is extremely important because if a supplement cannot cross the blood-brain barrier, it cannot improve or have an effect on cognition.

Some of sulbutiamine’s benefits as a nootropic include helping to improve memory, learning capacity, decision-making, synaptic plasticity, problem solving, and planning skills. There is also a lot of evidence showing that sulbutiamine is capable of partially treating degenerative cognitive conditions like Alzheimer’s and possibly even schizophrenia. Another benefit of this supplement is that it can allow neurons to communicate more efficiently. This will in turn make thoughts and perception seem like they are more fluid and faster, causing an improvement in reflexes, attention, and mental alertness. Sulbutiamine is also known to increase levels of dopamine, bringing about a positive effect on mood and a feeling of pleasure. For this reason, many have used the supplement to reduce anxiety and depression.

The recommended dosage of sulbutiamine is around 200mg to 500mg up to two times a day with food. As with any nootropic, it’s a good idea to start with the smallest dose first and then gradually increasing to a comfortable dose. Sulbutiamine is usually very well tolerated among healthy adults but there are some side effects that we should be aware of. Some side effects of this supplement include mood swings, difficulties in falling asleep, suppressed appetite, and negative outcomes on people with bipolar mood disorder.





  • Kang KD1, Majid AS, Kim KA, Kang K, Ahn HR, Nho CW, Jung SH. Sulbutiamine counteracts trophic factor deprivation induced apoptotic cell death in transformed retinal ganglion cells. Neurochem Res. 2010 Nov;35(11):1828-39. PMID: 20809085.
  • Encephale. 2007 Mar-Apr;33(2):211-5. PMID: 17675917.
  • Bizot JC1, Herpin A, Pothion S, Pirot S, Trovero F, Ollat H. Chronic treatment with sulbutiamine improves memory in an object recognition task and reduces some amnesic effects of dizocilpine in a spatial delayed-non-match-to-sample task. Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jul;29(6):928-35. PMID: 15951087.

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