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Sunifiram Dosage

Daily Dose of Sunifiram: 4-8mg up to 3 times a day

Supplementing with Sunifiram

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Sunifiram is a new nootropic, or smart drug, that works very similarly to racetams like piracetam and aniracetam. Nootropics are supplements that enhance cognitive function, improve concentration, and boost memory. Many people use nootropics to increase attention spans and to help themselves focus and study. These smart drugs have a low toxicity and can be taken for long term use. They are able to improve cognitive functions without any of the negative side effects that are commonly associated with brain stimulants. How do they work exactly? Nootropics like Sunifiram will not give you a higher IQ or make you smarter instantly but they will increase your brain function by increasing the production of various neurotransmitters. Improved concentration, better memory, mood elevation, increased processing ability for mental work, and longer attention spans are all results of a higher presence of neurotransmitters.

Sunifiram is an Ampakine that, according to research, is more than 1000 times more potent than Piracetam. The primary effect of taking Sunifiram is stimulation of AMPA receptors, which are responsible for how much glutamate is produced in the brain. Glutamate is probably the most important neurotransmitter in the brain because it is responsible for communicating excitatory transmissions, forming connections between synapses, and for regulating brain cell survival. The brain’s cognitive abilities would be greatly impaired without glutamate.

Sunifiram is highly potent compared even to the strongest racetams like Pramiracetam, and positive results can be seen even with a dosage as small as 4mg. The recommended dosage is 5-8mg a day, high doses like 10mg can cause a stimulant effect that is similar to the drug Adderall. Taking 10mg a day is not toxic but it can cause increased body temperature and perspiration. Some suggest taking it in very small doses and gradually increasing over time.



  • Moriguchi S1, Tanaka T, Narahashi T, Fukunaga K. Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. Hippocampus. 2013 Oct;23(10):942-51. PMID: 23733502.
  • Moriguchi S1, Tanaka T, Tagashira H, Narahashi T, Fukunaga K. Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. Behav Brain Res. 2013 Apr 1;242:150-7. PMID: 23295391.
  • Martini E1, Salvicchi A, Ghelardini C, Manetti D, Dei S, Guandalini L, Martelli C, Melchiorre M, Cellai C, Scapecchi S, Teodori E, Romanelli MN. Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. Bioorg Med Chem. 2009 Nov 1;17(21):7606-14. PMID: 19786353.

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