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Tianeptine Dosage

Daily Dose of Tianeptine: 12.5g 2 to 3 times daily

Supplementing with Tianeptine

Tianeptine is an antidepressant that has been shown to decrease extracellular serotonin levels. Photo Credit: https://www.flickr.com/photos/canonsnapper/

Tianeptine is an anti-depressant that is primarily used to treat major depressive disorder but it is also used to treat asthma and irritable bowel syndrome. It is considered one of the most effective treatments for major depressive episodes that range from mild to severe. It has structural similarities with tricyclic antidepressants or SSRI’s (selective serotonin reuptake inhibitors) but it lacks their disadvantages and has more positive benefits than just being an anti-depressant. Tianeptine has also been used as a nootropic and a study shows that it can improve memory and learning abilities by increasing elastic memory.

Not only that, but reports have also shown that it produced feelings of wellbeing and mental clarity. It is advertised to have mood lifting effects and as being neuroprotective and anxiolytic (reducing anxiety). One significant attribute of tianeptine is that it does not appear to cause any type of tolerance, addiction, or act as a sedative substance. In addition, it may be able to treat obsessive compulsive disorders, social anxiety, and even some eating disorders. There may even be a possibility that it can be used to treat neuro-degenerative disorders like Alzheimer’s disease, cerebral aging, and multiple sclerosis. This drug is approved for use in France and a few other countries in the European Union. The delay in its acceptance in English speaking countries seems to have been caused by its early research being in French as it was developed at the French Society of Medical Research in the 1960s.

Tianeptine is considered very safe and generally tolerated by healthy adults. Some mild side effects of this drug include dry mouth, constipation, dizziness, drowsiness, low blood pressure, insomnia, and possibly vivid dreams. If you are suffering from depression, it is best to first talk to your doctor about tianeptine or any other form of treatment you are considering to take. A common recommended dose would be a 12.5g pill or tablet taken two or three times a day with or without food.



  • Eksp Klin Farmakol. 2014;77(5):10-4. PMID: 25033565.
  • Gassaway MM1, Rives ML2, Kruegel AC1, Javitch JA3, Sames D1. The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist. Transl Psychiatry. 2014 Jul 15;4:e411. PMID: 25026323.
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